Pamela Mancini, Ph.D.

Pamela Mancini, Ph.D., is a technical specialist in Sterne Kessler’s Biotechnology & Chemical Practice Group, where she assists in the preparation and prosecution of US and foreign patent applications, as well as freedom-to-operate and patentability analyses.

Pamela has over 10 years of hands-on research experience and her principal areas of scientific expertise include molecular and cellular biology, genetics and genetically engineered animal models, RNA interference, CRISPRs, plasmid vectors engineering, next generation sequencing, cell signaling and immunology.

Prior to joining Sterne Kessler, Pamela worked as a research scientist at Columbia University, after completing two post-doctoral fellowships at the Icahn School of Medicine at Mount Sinai and at Cincinnati Children Hospital Medical Center. Pamela’s post-doctoral work focused on investigating the cellular and molecular basis of congenital defects. Her work on tracheo-esophageal separation, and in particular on the role of epithelial remodeling downstream of Shh signaling, contributed to the understanding of the cellular and molecular basis of this morphogenetic process. She also conducted research on neural tube closure birth defects, specifically on the mechanism of planar cell polarity establishment in the neural plate and the role of Wnt signaling in this developmental process. Her Ph.D. thesis focused on retinogenesis and on the function of Otx genes in early anterior development.

Pamela obtained her Ph.D. in Biological and Molecular Science at the University of Pisa, Italy, where she also obtained her bachelor’s degree in Molecular and Biological Science and her master’s degree in Biomolecular Science and Technology, both magna cum laude. Pamela is also a qualified biochemical technician for the industry.

Pamela is the first author and coauthor of scientific articles published in peer-reviewed journals.

Pamela is fluent in Italian and English.

Technical Publications

• Imaging Planar Cell Polarity Proteins in Xenopus Neuroectoderm. In: Chang, C., Wang, J. (eds) Cell Polarity Signaling. Methods in Molecular Biology, vol. 2438. Humana, New York, NY. Ossipova, O., Mancini, P., Sokol, S.Y. (2022).
• The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate. Mancini et al., 2021 (Biology Open)
• Endosome-mediated epithelial remodeling downstream of Hedgehog/Gli is required for trachoesophageal separation. Nasr and Mancini et al., 2019 co-first authorship (Developmental Cell)
• A molecular atlas of Xenopus respiratory system development. Rankin, Thi Tran, Wlizla and Mancini et al., 2015 (Developmental Dynamics)
• Identification and evolution of molecular domains involved in differentiating the cement gland promoting activity of Otx proteins in Xenopus laevis. Mancini et al., 2013 (Mechanisms of Development)