Thomas “Tom” D. Murray, IV, Ph.D., is a patent agent in Sterne Kessler’s Biotechnology and Chemical Practice group. Tom prepares and prosecutes patent applications; assists in the formulation of invalidity, non-infringement, freedom-to-operate, clearance, and patentability opinions; and provides litigation document review support. Prior to joining Sterne Kessler, Tom gained patent prosecution experience in diverse technology areas such as microfluidics, antibody- and CAR T-cell-based therapeutics, cell culture methods, and polymer chemistry at a general practice law firm in Alexandria, VA, where he began his career in intellectual property as a patent technical specialist and subsequently as a patent agent.
Tom focused his Ph.D. studies at the University of California, Berkeley, on the design and development of microfluidic devices for investigating the structure and function of biological macromolecules involved in DNA replication initiation. Specifically, Tom designed and manufactured PDMS-based microdroplet microfluidic devices for use in biochemical assays. Additionally, he developed novel, high-transparency silicon nitride-based microfluidic devices for high-resolution molecular imaging experiments and collaborated with scientists at the Linac Coherent Light Source at Stanford (the world’s first hard x-ray free electron laser facility) and at Argonne National Laboratory for data collection. In addition to microfluidics and microfabrication, Tom’s doctoral research experience also included: construction and use of a single molecule microscope; fluorescence-based techniques (such as FRET); biochemistry; molecular biology; and macromolecular structure determinations.
Prior to his graduate studies, Tom spent three years as a research technician for Prof. Kathryn Ferguson in the Department of Physiology at the University of Pennsylvania studying the structure and function of the Epidermal Growth Factor Receptor (EGFR) family of receptor tyrosine kinases. In this role, Tom refined his skills in molecular biology while also gaining experience in X-ray crystallography, biochemistry, protein expression (both bacterial and insect cell), and protein purification techniques.
Tom earned his B.A. in Biology (cum laude), with a concentration in molecular biology, from the University of Pennsylvania where he conducted undergraduate research in the laboratory of Prof. Erle Robertson in the Department of Virology. As an undergraduate research assistant, Tom gained experience in molecular biology and mammalian cell protein expression of viral proteins from the cancer-causing Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus.
- Murray, T. D., Lyubimov, A. Y., Ogata, C. M., Vo, H., Uervirojnangkoorn, M., Brunger, A. T. and Berger, J. M. A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions. Acta Crystallographica Section D, 2015, 71, 1987-1997
- Lyubimov, A. Y., Murray, T. D., Koehl, A., Araci, I. E., Uervirojnangkoorn, M., Zeldin, O. B., Cohen, A. E., Soltis, S. M., Baxter, E. L., Brewster, A. S., Sauter, N. K., Brunger, A. T. and Berger, J. M. Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array. Acta Crystallographica Section D, 2015, 71, 928-940
- Lyubimov, A.Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A.S., Murray, T.D., Sauter, N.K., Berger, J.M., Weis, W.I., and Brunger, A.T. IOTA : integration optimization, triage and analysis tool for the processing of XFEL diffraction images. Journal of Applied Crystallography, 2016, 49, 1-8