James M. Eaton, Ph.D., is an associate in Sterne Kessler’s Biotechnology & Chemical Practice Group. James assists in worldwide procurement of patents in the biotechnology, chemical, and pharmaceutical industries. His experience also extends to assisting in the preparation of validity, infringement, freedom to operate, and patentability opinions.
James’ technical expertise focuses on biochemistry and molecular biology. While earning his Ph.D., James elucidated molecular mechanisms controlling insulin signaling and fat synthesis in adipocytes. He also has experience in small molecule synthesis. During his graduate studies, he received a Pharmacological Sciences training grant from the National Institutes of Health.
James earned his J.D. from the University of Richmond School of Law. He received a Ph.D. in Pharmacology and M.S. in Biological and Physical Science from the University of Virginia, and a B.A. in Chemistry from Kenyon College.
- Coauthor, Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice, FASEB J., 2019, 33(1): 652-667.
- Coauthor, The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3, J. Biol. Chem., 2017, 292(50): 20481-20493.
- Coauthor, Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity, JIMD Rep., 2015, 23:113-122.
- Coauthor, Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes, Proc. Natl. Acad. Sci. 2014, 111(49): 17450-17455.
- Coauthor, Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor, Am. J. Physiol. Endocrinol. Metab., 2014, 307(3): E305-E315.
- Coauthor, Inhibited Insulin Signaling in Mouse Hepatocytes Is Associated with Increased Phosphatidic Acid but not Diacylglycerol, J. Biol. Chem., 2015, 290(6): 3519-3528.
- Coauthor, Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation, J. Biol. Chem., 2014 289(26): 18055-18066.
- Coauthor, Phosphorylation of Lipin 1 and Charge on the Phosphatidic Acid Head Group Control Its Phosphatidic Acid Phosphatase Activity and Membrane Association, J. Biol. Chem., 2013, 288(14): 9933-9945.
- Coauthor, Assembly of High Molecular Weight Complexes of Lipin on a Supported Lipid Bilayer Observed by Atomic Force Microscopy, Biochemistry, 2013, 52(30): 5092-5102.